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Content Details. Hematomatous swellings associated with prolonged prothrombin times have been reported, but the clinical significance is unknown.
Leukopenia and anemia have been reported in at least one patient. Elevated liver enzymes, elevated bilirubin, and hepatitis have been reported during postmarketing experience.
Cardiovascular side effects have included tachycardia and orthostatic hypotension. EKG changes, including prolonged PR interval, flattened T waves and peaked T waves, have been reported in single cases.
Hypotension primarily orthostatic hypotension has been reported during postmarketing experience. Dermatologic side effects have included pruritus, rash, and urticaria.
Toxic epidermal necrolysis and Stevens-Johnson syndrome have been reported during postmarketing experience. Single dose therapy with ivermectin has been associated with a low rate of serum aminotransferase elevations.
A single case of clinically apparent liver injury has been reported after ivermectin use The onset of injury occurred 1 month after a single dose and was characterized by a hepatocellular pattern of serum enzyme elevations without jaundice.
Recovery was rapid and complete. The mechanism by which it might cause liver injury is unknown Conditions Procedures. Drugs Supplements Vitamins and Minerals.
Contents What is ivermectin Ivermectin for humans How should ivermectin be used? Ivermectin may be prescribed for other uses; ask your doctor or pharmacist for more information.
Differential susceptibilities of Anopheles albimanus and Anopheles stephensi mosquitoes to ivermectin. Malaria Journal.
Toward the elimination of lymphatic filariasis by treatment update and impact assessment for the endgame. Expert Rev Anti Infect Ther.
The pharmacokinetics and interactions of ivermectin in humans—a mini-review. Inquiries concerning all rights should be addressed ivermectin tablet name the author's representative at debrah.
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Ivermectin is available as a generic prescription drug in the U. The formulation for rosacea treatment is sold as Soolantra.
While in development, it was assigned the code MK by Merck. Ivermectin is routinely used to control parasitic worms in the gastrointestinal tract of ruminant animals.
These parasites normally enter the animal when it is grazing, pass the bowel and set and mature in the intestines, after which they produce eggs which leave the animal via its droppings and can infest new pastures.
Ivermectin is effective in killing some, but not all, of these parasites. In dogs it is routinely used as prophylaxis against heartworm.
Dogs with defects in the P-glycoprotein gene MDR1 , often collie-like herding dogs, can be severely poisoned by ivermectin. The mnemonic "white feet, don't treat" refers to Scotch collies that are vulnerable to ivermectin.
Ivermectin is sometimes used as an acaricide in reptiles, both by injection and as a diluted spray. While this works well in some cases, care must be taken, as several species of reptiles are very sensitive to ivermectin.
Use in turtles is particularly contraindicated. Ivermectin is being studied as a potential antiviral agent against chikungunya and yellow fever.
In , this antiparasitic drug was demonstrated as a novel ligand of farnesoid X receptor FXR ,   a therapeutic target for Nonalcoholic Fatty Liver Disease.
Ivermectin is also of interest in the prevention of malaria , as it is toxic to both the malaria plasmodium itself, and the mosquitos that carry it.
A preprint published in April claimed benefits of ivermectin in the treatment of COVID, but it was a retrospective study based on questionable hospital data from Surgisphere and was withdrawn at the end of May.
From Wikipedia, the free encyclopedia. IUPAC name. October 27, Retrieved October 27, This article incorporates text from this source, which is in the public domain.
Archived from the original on January 3, Retrieved January 16, Drug Discovery a History. Elsevier Health Sciences.